Searching-waiting strategy: a candidate for
an evolutionary model of depression?
Thierry B, Steru L, Chermat R, Simon P
Arch Gen Psychiatry 2000 Jan; 57(1):14-20
ABSTRACTThe model proposed here assumes that depressive disorders could reflect an extreme state of a current behavioral strategy. According to this model, a subject facing a problem of survival without apparent solution may choose between two behavioral patterns: searching for a solution or waiting for that solution to occur. This choice can be made after one or several estimations of the cost and benefit attached to each of these alternatives. Two of the main behavioral models of depression are interpreted according to this model: namely, infant response to maternal separation in monkeys and "behavioral despair" in rodents. Practical and theoretical consequences of this model are discussed.SSRIs
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